19 articles - From Friday Dec 27 2024 to Friday Jan 03 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
|---|
Reporting of nutritional screening, status and intake in trials of nutritional and physical rehabilitation following critical illness: a systematic review. Few RCTs of physical rehabilitation measure and report nutritional or related variables. Future studies should measure and report specific nutritional factors that could impact physical and functional recovery to support interpretation where studies do not show benefit. A protocol was pre-registered on PROSPERO (CRD42022315122). |
| J Crohns Colitis |
Artificial intelligence-enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in Ulcerative Colitis: a systematic review, meta-analysis and meta-regression. AI shows significant potential for assessing histological remission in UC and performs comparably to pathologists. Future research should focus on standardised, large-scale studies to minimise heterogeneity and support widespread AI implementation in clinical practice. |
| Pancreatology |
Associations between ABO, FUT2 and chronic pancreatitis: A comprehensive meta-analysis of multiple cohorts and public biobanks. No association was found between lead SNPs of ABO or FUT2 and CP in meta-analysis, nor was there an association between ABO blood group or FUT2 secretor status and CP in Chinese cohort. ABO and FUT2 might play limited role in CP development. |
Feasibility and clinical utility of endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling in pancreatic cancer: A systematic review and meta-analysis. Comprehensive genomic profiling of PDAC using EUS-TA-derived samples demonstrated feasibility in clinical settings. Approximately 18 % of patients undergoing CGP exhibited potentially actionable mutations, highlighting the potential for personalized therapeutic approaches. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Effect of Medium Chain Triglycerides and Whey Protein Isolate Preloads on Glycaemia in Type 2 Diabetes: A randomised crossover study. Sequential consumption of MCT and WPI preloads did not affect diurnal or 24h glycaemia but lowered PPG and 24h glycaemic variability in individuals with T2D. These effects were associated with increased circulating β-hydroxybutyrate, PYY and GIP, and suppression of appetite. Clinical trial registry number ClinicalTrials.gov Identifier NCT04905589 URL OF REGISTRATION |
The Relationship Between A High-Fat Diet, Gut Microbiome, and Systemic Chronic Inflammation: Insights from Integrated Multi-Omics Analysis. Microbial dysbiosis appears to be an important mechanism for HFD-induced SCI. The Lachnospiraceae_FCS020 group may act as a key genus in HFD-mediated elevation of IL-2RA. |
| Inflamm Bowel Dis |
Jacalin Attenuates Colitis-Associated Colorectal Carcinogenesis by Inhibiting Tumor Cell Proliferation and Intestinal Inflammation. Collectively, our findings demonstrated that jacalin suppresses CAC development, highlighting its anti-inflammatory and antitumoral role in the AOM/DSS-induced model. |
| J Crohns Colitis |
Anti-TNF Non-Response in Ulcerative Colitis: Correcting for Mucosal Drug Exposure Reveals Distinct Cytokine Profiles. We incorporated MDE in mucosal cytokine research to avoid bias due to insufficient presence of anti-TNF. When applied to mucosal cytokines previously linked to (N)R, IL-6 appears to drive inflammation in TNFi resistant UC patients, while OSM seems to parallel inflammation and does not cause refractoriness. |
Histologic and Endoscopic Findings Are Highly Correlated in a Prospective Cohort of Patients With Inflammatory Bowel Diseases. In a real-world setting, endoscopic inflammation predicted histologic inflammation with high accuracy. In patients with a Rutgeerts score of i0, microscopic inflammation in neo-TI biopsies did not predict more aggressive disease behavior over the next 4 years. These results have implications for the design of clinical trials, suggesting the use of endoscopic healing as an endpoint. |
| Pancreatology |
Endoscopic ultrasound is useful for the risk stratification of mucinous pancreatic cystic lesions: A long-term prospective study. EUS-FNA is useful for the risk stratification of mucinous PCLs. The low incidence of adenocarcinoma over time after a negative EUS-FNA may allow for a less resource intensive surveillance strategy. |
Frozen section analysis of pancreatic resection margins during pancreaticoduodenectomy for pancreatic adenocarcinoma is not affected by neoadjuvant therapy. The histopathological changes occurring in the pancreas PNAT for PDAC do not affect the histopathological interpretation of FS analysis of PRMs, and the accuracy of FS analysis is similar in the PNAT and TN patients. |
No definite associations between opioid doses and severity of acute pancreatitis - Results from a multicentre international prospective study. The association between opioid doses and AP severity was dose-dependent with cumulative opioid doses but not with daily doses. In the absence of adequate evidence and potential reverse causation bias, future studies are warranted to assess the safety of opioids in AP. |
Onset of pancreatic cancer before and after acute pancreatitis: A multicenter longitudinal cohort study. Idiopathic AP and pseudocyst formation significantly elevate the risk of PC, particularly within two years. These findings underscore the need for structured follow-up and early screening in idiopathic AP cases to improve PC detection and survival outcomes. |
Optimal indication of adding pancreatic juice cytology in the diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas. Although PJC is generally not recommended for patients with IPMN, it is worth considering for the determination of treatment strategies in patients with abrupt changes in the caliber of the pancreatic duct with distal pancreatic atrophy. |
Patient-derived organoids from pancreatic cancer after pancreatectomy: Feasibility and organoid take rate in treatment-naïve periampullary tumors. In the current study, we found that PDOs could be established from resected pancreatic tumors in over half of resected periampullary tumors, and highest in PDACs. As such, generating a pancreatic cancer PDO biobank for translational research was feasible after cryopreservation. |
Time between pancreatic cancer diagnosis and treatment initiation and survival in the U.S. Military Health System. Results Overall, median time-to-treatment was 3 weeks and 95 % of patients received treatment within 12 weeks. Time-to-treatment >6 weeks was associated with a statistically significant lower risk of death (AHR = 0.77, 95 % CI = 0.61-0.98) compared to time-to-treatment 12 weeks) with survival. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
|---|
misc publications eg case reports, tools of the trade, images of the month, etc…